Hydrazine hydrate (1:1) → HCID 178477869, compound

HRID 456629Notes

Reaction equation

HRID 456629 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[CH:14]=[CH:13][NH:12][CH:11]=2)=O)=[CH:6][CH:5]=[C:4]([Cl:15])[N:3]=1.O.[NH2:17][NH2:18]>C(O)C>[Cl:15][C:4]1[N:3]=[C:2]2[NH:17][N:18]=[C:8]([C:10]3[CH:14]=[CH:13][NH:12][CH:11]=3)[C:7]2=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436868(2,6-dichloro-pyridin-3-yl)-(1H-pyrrol-3-yl)-methanone

Product 1

HCID 178477869HCID 178477869, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of (2,6-dichloro-pyridin-3-yl)-(1H-pyrrol-3-yl)-methanone (300 mg) and hydrazine hydrate (0.2 mL) in ethanol (10 mL) was heated at 90° C. for 20 hours. The reaction was concentrated to 6 mL, diluted with water (2 mL) and cooled. The precipitate was collected and dried to give 160 mg of the titled compound.

Workup

  1. concentrationThe reaction was concentrated to 6 mL
  2. additiondiluted with water (2 mL)
  3. temperaturecooled
  4. customThe precipitate was collected
  5. customdried

Sources & evidence

ORD record
ord-e8c5a7615b094a128dc5606ce408285f
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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