Triethylamine → HCID 135432876, compound

HRID 456649Notes

Reaction equation

HRID 456649 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7](OC(=O)C(C)(C)C)[N:6]=[C:5]2[C:18]1[NH:19][CH:20]=[CH:21][CH:22]=1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=1.C(N(CC)CC)C>C(Cl)Cl>[NH:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([NH:1][C:23](=[O:30])[C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)[CH:3]=2)[NH:7][N:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 417436Pyridine-4-carbonyl chlorideHCID 136358049HCID 136358049, compound

Product 1

HCID 135432876HCID 135432876, compoundYield 104.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,2-Dimethyl-propionic acid 5-amino-3-(1H-pyrrol-2-yl)-indazol-1-yl ester (0.38 mmol) was coupled with isonicotinoyl chloride (0.4 mmol) (Aldrich, Milwaukee, Wis.) and triethylamine in DCM at 0° C. to give 120 mg of the titled compound as a light yellow solid.

Sources & evidence

ORD record
ord-cd59e749b76049bf95308e179f83d795
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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