Hydrazine hydrate (1:1) → HCID 135465897, compound

HRID 456653Notes

Reaction equation

HRID 456653 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]([C:9]2[CH:14]=[C:13]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:11][C:10]=2Cl)=O)[NH:5][CH:6]=1.O.[NH2:20][NH2:21]>C1(C)C=CC=CC=1.CN1CCCC1=O>[Br:1][C:2]1[CH:3]=[C:4]([C:7]2[C:9]3[C:10](=[CH:11][CH:12]=[C:13]([N+:15]([O-:17])=[O:16])[CH:14]=3)[NH:21][N:20]=2)[NH:5][CH:6]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436881HCID 18436881, compound

Product 1

HCID 135465897HCID 135465897, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of (4-bromo-1H-pyrrol-2-yl)-(2-chloro-5-nitro-phenyl)-methanone (400 mg) and hydrazine hydrate (0.4 mL) in toluene (6 mL) and 1-methyl-2-pyrrolidinone (1.5 mL) was heated at 110° C. for 1 hour. The reaction was concentrated, the residue was triturated with 10% ethyl acetate in DCM to give 210 mg of the titled compound as an orange solid.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe residue was triturated with 10% ethyl acetate in DCM

Sources & evidence

ORD record
ord-1570924c76e84598a78fc59844962f21
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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