Hydrazine hydrate (1:1) → HCID 178524266, compound

HRID 456656Notes

Reaction equation

HRID 456656 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]([C:11]([C:13]2[C:14](Cl)=[N:15][CH:16]=[CH:17][CH:18]=2)=O)=[CH:9][CH:10]=1)=[O:5])C.O.[NH2:21][NH2:22]>C(O)C>[NH:21]1[C:14]2=[N:15][CH:16]=[CH:17][CH:18]=[C:13]2[C:11]([C:8]2[NH:7][C:6]([C:4]([OH:3])=[O:5])=[CH:10][CH:9]=2)=[N:22]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 76853860ethyl 5-(2-chloronicotinoyl)-1H-pyrrole-2-carboxylate

Product 1

HCID 178524266HCID 178524266, compoundYield 19.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid ethyl ester (0.5 g) and hydrazine hydrate (0.7 g) in ethanol was heated at 80° C. for 24 hours. The resulted precipitate was collected by vacuum filtration, washed with water and dried to give 80 mg of the titled compound.

Workup

  1. filtrationThe resulted precipitate was collected by vacuum filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-8b014a05f9034f4b9e1b1f3f1fd5a4da
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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