Hydrazine hydrate (1:1) → HCID 178468778, compound

HRID 456657Notes

Reaction equation

HRID 456657 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:11]([C:13]2[C:14](Cl)=[N:15][CH:16]=[CH:17][CH:18]=2)=O)=[CH:9][CH:10]=1)=[O:5])[CH3:2].O.[NH2:21][NH2:22]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([C:11]2[C:13]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[NH:22][N:21]=2)=[CH:9][CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 76853860ethyl 5-(2-chloronicotinoyl)-1H-pyrrole-2-carboxylate

Product 1

HCID 178468778HCID 178468778, compoundYield 33.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 5-(2-chloro-pyridine-3-carbonyl)-1H-pyrrole-2-carboxylic acid ethyl ester (0.5 g) (from Example 30) and hydrazine hydrate (0.7 g) in ethanol was heated at 80° C. for 24 hours. The precipitate was filtered off and the filtrate was concentrated to give 156 mg of the titled compound.

Workup

  1. filtrationThe precipitate was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-8557a4859ded40aa82670f7a51415896
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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