Hydrazine hydrate (1:1) → HCID 178527317, compound

HRID 456679Notes

Reaction equation

HRID 456679 reaction equation
[C:1]1([S:7]([N:10]2[CH:14]=[CH:13][CH:12]=[C:11]2[C:15]([C:17]2[C:18](Cl)=[N:19][CH:20]=[CH:21][CH:22]=2)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:25][NH2:26]>C(O)C>[C:1]1([S:7]([N:10]2[CH:14]=[CH:13][CH:12]=[C:11]2[C:15]2[C:17]3[C:18](=[N:19][CH:20]=[CH:21][CH:22]=3)[NH:26][N:25]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18436866(1-benzenesulfonyl-1H-pyrrol-2-yl)-(2-chloro-pyridin-3-yl)-methanone

Product 1

HCID 178527317HCID 178527317, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of (1-benzenesulfonyl-1H-pyrrol-2-yl)-(2-chloro-pyridin-3-yl)-methanone (150 mg) and hydrazine hydrate (0.15 mL) in ethanol (3.5 mL) was heated at 90° C. for overnight. The reaction was concentrated, diluted with ethyl acetate, washed with base and water, dried and concentrated to give 75 mg of the titled compound as a white solid.

Workup

  1. concentrationThe reaction was concentrated
  2. additiondiluted with ethyl acetate
  3. washwashed with base and water
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5d87d57c9bb84d86bdd354d24a7bbeee
Source dataset
uspto-grants-2007_03
Patent number
US07186716B2

Reaction notes

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