Ethyl oxoacetate → HCID 178472742, compound

HRID 456726Notes

Reaction equation

HRID 456726 reaction equation
[C:1]1([C@@H:7]([NH2:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]([O:14][CH2:15][CH3:16])(=[O:13])[CH:11]=O>C1(C)C=CC=CC=1>[C:1]1([C@H:7](/[N:9]=[CH:11]\[C:10]([O:14][CH2:15][CH3:16])=[O:13])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 70211Ethyl oxoacetateHCID 758181-Phenethylamine, (-)-

Product 1

HCID 178472742HCID 178472742, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a (1S)-1-phenylethanamine (77.4 mL), was added a solution of ethyl glyoxylate in toluene (45–50%, 123 mL) at room temperature. After 1 hr, the mixture was evaporated in vacuo. The residue (120 g) was used in the next step without further purification.

Workup

  1. customthe mixture was evaporated in vacuo
  2. customThe residue (120 g) was used in the next step without further purification

Sources & evidence

ORD record
ord-80f9469bc3c646f8a01f1776fe8e0bb4
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

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