Hydrochloric Acid → HCID 11426167, compound

HRID 456729Notes

Reaction equation

HRID 456729 reaction equation
[C:1]([C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8]([C@@H:10]1[C@@H:15]2[CH2:16][CH2:17][C@@H:12]([CH2:13][C@H:14]2[OH:18])[N:11]1C(OC(C)(C)C)=O)=[O:9])#[N:2].[ClH:26]>O1CCOCC1>[ClH:26].[OH:18][C@@H:14]1[CH2:13][C@@H:12]2[CH2:17][CH2:16][C@H:15]1[C@@H:10]([C:8]([N:4]1[CH2:5][CH2:6][CH2:7][C@H:3]1[C:1]#[N:2])=[O:9])[NH:11]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86598891HCID 86598891, compound

Product 1

HCID 11426167HCID 11426167, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl (1S,3S,4S,5R)-3-{[(2S)-2-cyano-1-pyrrolidinyl]carbonyl}-5-hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate obtained in Example 2-7 (2.0 g) in dioxane (10 mL), was added 4N HCl in dioxane (1.43 mL) at room temperature.

Sources & evidence

ORD record
ord-d527e40bd24743c5843bad9a8a9d38a9
Source dataset
uspto-grants-2007_03
Patent number
US07186731B2

Reaction notes

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