Benzyl Alcohol → 3-Benzyl 2-tert-butyl (1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate

HRID 456764ノート

反応式

HRID 456764 の反応式
[C:1]([O:5][C:6]([N:8]1[C@H:13]([C:14]([OH:16])=[O:15])[C@H:12]2[CH2:17][C@@H:9]1[C@H:10]([OH:18])[CH2:11]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:19](O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1(N=C=NC2CCCCC2)CCCCC1>ClCCl.CN(C)C1C=CN=CC=1>[OH:18][C@H:10]1[C@H:9]2[CH2:17][C@H:12]([C@@H:13]([C:14]([O:16][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:15])[N:8]2[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:11]1

参加物

6

反応物 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 69133789(1R,3S,4S,6R)-2-(tert-Butoxycarbonyl)-6-hydroxy-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid

生成物 1

HCID 865989173-Benzyl 2-tert-butyl (1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2,3-dicarboxylate

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of (1R,3S,4S,6R)-2-(tert-butoxycarbonyl)-6-hydroxy-2-azabicyclo[2.2.1]heptane-3-carboxylic acid obtained in Example 5-6 (1.0 g) in dichloromethane (8 mL), were added benzyl alcohol (504 mg), dicyclohexylcarbodiimide (962 mg) and 4-(dimethylamino)pyridine (12 mg). The mixture was stirred at room temperature for 20 hrs.

出典と根拠

ORDレコード
ord-575f6b62b8f54b22bebc7f124a76378a
出典データセット
uspto-grants-2007_03
特許番号
US07186731B2

反応ノート

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