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HRID456851

反应详情

EQUATION

反应方程式

HRID 456851 的结构方程式

REACTANTS

反应物

4
结构：N#Cc1cccc(Br)c1
HCID23381

Benzonitrile, m-bromo-

C7H4BrN

结构：c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1
HCID634876

2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl

C44H32P2

结构：CC(C)(C)OC(=O)N1CCC(N)CC1
HCID1268291

4-Amino-1-Boc-piperidine

C10H20N2O2

结构：CC(C)(C)[O-].[Na+]
HCID23676156

Sodium t-butoxide

C4H9NaO

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC(Nc2cccc(C#N)c2)CC1
HCID25223796

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)[O-].CC(=O)[O-].[Pd+2]
催化剂HCID167845

Diacetatopalladium

C4H6O4Pd

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

To a dry flask containing 4-amino-piperidine-1-carboxylic acid tert-butyl ester (5.0 g; 1.2 eq) and 3-bromobenzonitrile (3.79 g; 1.0 eq) in dry toluene (80 mL) was added BINAP (390 mg; 0.03 eq), palladium acetate (94 mg; 0.02 eq) and sodium tert-butoxide (2.8 g; 1.4 eq).