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HRID456989

反应详情

EQUATION

反应方程式

HRID 456989 的结构方程式

REACTANTS

反应物

4
结构：BrBr
HCID24408

Bromine

Br2

结构：O=S([O-])([O-])=S.[Na+].[Na+]
HCID24477

Sodium thiosulfate

Na2O3S2

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：COc1ccc2nc(S(C)(=O)=O)ccc2c1
HCID11253377

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2nc(S(C)(=O)=O)ccc2c1Br
HCID22139732

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg, 1 mmole ) in CH2Cl2 was treated with 2 mmoles Br2 and stirred for 1 day. The mixture was poured into a solution of NaHCO3 and sodium thiosulfate. The product was extracted with CH2Cl2. The organic layer was dried and evaporated to afford 5-bromo-2-methanesulfonyl-6-methoxy-quinoline, 287 mg (91%), as white crystals.

WORKUP

后处理

  1. extractionThe product was extracted with CH2Cl2
  2. customThe organic layer was dried
  3. customevaporated