Hydrochloric Acid → HCID 18439589, compound

HRID 457465Notes

Reaction equation

HRID 457465 reaction equation
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([CH2:14][S:15][CH3:16])[C:6]=1F)(=[O:4])=[O:3].[CH3:18][O:19][CH2:20][CH2:21][NH2:22].Cl>O>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([CH2:14][S:15][CH3:16])[C:6]=1[NH:22][CH2:21][CH2:20][O:19][CH3:18])(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 80182-MethoxyethylamineHCID 18439590HCID 18439590, compound

Product 1

HCID 18439589HCID 18439589, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2 g (7.2 mmol) of 4-methylsulfonyl-3-fluoro-2-methylthiomethylbenzoic acid were refluxed in 20 g (0.266 mol) of a 60% strength 2-methoxyethylamine solution in water for four days. The cold solution was acidified with concentrated HCl to a pH of 1 and extracted with EE. The organic solution was dried with MgSO4 and concentrated to completion. This gives a brown oil.

Workup

  1. extractionextracted with EE
  2. dry with materialThe organic solution was dried with MgSO4
  3. concentrationconcentrated to completion
  4. customThis gives a brown oil

Sources & evidence

ORD record
ord-40102b15a2f14ea98904d496ee1022cd
Source dataset
uspto-grants-2007_03
Patent number
US07189679B2

Reaction notes

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