反应详情

温度

125 °C

A mixture of 1,4-dibromonaphthalene (24.06 g, 84 mmol) and copper cyanide (6.02 g, 67 mmol) in DMF (85 mL) was heated to 125° C. overnight. The mixture was partially concentrated to remove DMF and the resulting residue washed with aqueous ammonium hydroxide and extracted with ethyl acetate. The organic layer was concentrated and purified by chromatography to yield 4-bromo-1-naphthonitrile (5.13 g, 26%).

1. concentrationThe mixture was partially concentrated
2. customto remove DMF
3. washthe resulting residue washed with aqueous ammonium hydroxide
4. extractionextracted with ethyl acetate
5. concentrationThe organic layer was concentrated
6. custompurified by chromatography