HRID458318

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12052

Silane, triethyl-

C6H16Si

结构：COc1ccc(CS[C@@H]2C[C@@H](CSCc3ccccc3)N(S(C)(=O)=O)C2)cc1

HCID69430272

未命名化合物

HCID131722655

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)N1C[C@H](S)C[C@H]1CSCc1ccccc1

HCID86584837

未命名化合物

收率 21%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

(TFA/triethylsilane for not labile methoxy-benzylsulfanyl, Method 2): 100 mg (0.23 mmol) of (2S,4R)-2-benzylsulfanylmethyl-1-methanesulfonyl-4-(4-methoxy-benzylsulfanyl)-pyrrolidine was dissolved in 8.2 ml TFA and treated at 0° C. with 0.35 ml (2.38 mmol) triethylsilane. The reaction was warmed up over night, heated 2.5 min at 80° C. and evaporated. Flash silica gel column (CH2Cl2/EtOAc 99:1) gave 15 mg (21%)of (3R,5S)-5-benzylsulfanylmethyl-1-methanesulfonyl-pyrrolidine-3-thiol, mp 101.5–103.5° C., MS: 318 (MH+).

WORKUP

后处理

temperatureThe reaction was warmed up over night
customevaporated