Hydrochloric Acid → 2-oxo-3-(2-pyridinyl)-1-Imidazolidineacetic acid

HRID 458551Notes

Reaction equation

HRID 458551 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:5][CH2:4][N:3]1[CH2:13][C:14]([O:16]C(C)(C)C)=[O:15].Cl>CCOC(C)=O>[O:1]=[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:5][CH2:4][N:3]1[CH2:13][C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86606174tert-Butyl (2-oxo-3-pyridin-2-ylimidazolidin-1-yl)acetate

Product 1

HCID 184426422-oxo-3-(2-pyridinyl)-1-Imidazolidineacetic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl 2-oxo-3-pyridin-2-ylimidazolidin-1-yl)acetate from Step B (150 mg, 0.54 mmol) in EtOAc (10 mL) at 0° C. was saturated with HCl (g). The mixture was stood at 0° C. for a total of 30 min, then concentrated in vacuo to give the title compound as a white solid. MS: m/z=222 (M+1).

Workup

  1. customat 0° C.
  2. customwas stood at 0° C. for a total of 30 min
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-0ec09fb0e8b2466db772b9296be7d620
Source dataset
uspto-grants-2007_03
Patent number
US07192954B2

Reaction notes

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