HRID459106

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID72279

6-Hydroxyflavone

C15H10O3

HCID5363146

Diisopropyl azodicarboxylate

C8H14N2O4

HCID5462977

(E)-Diethyl azodicarboxylate

C6H10N2O4

HCID69423017

未命名化合物

PRODUCTS

生成物

结构：CO[C@@H](Cc1ccc(C#CCCOc2ccc3oc(-c4ccccc4)cc(=O)c3c2)cc1)C(=O)O

HCID58822632

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

The title compound was prepared from 3-[4-(4-Hydroxy-but-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 47, Step A and 6-hydroxyflavone following the standard coupling-hydrolysis procedure A using toluene as solvent and DIAD instead DEAD. MS(ES) for C29H24O6 [M+H]+: 469.2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-51a768f559a64c338bf48d6917780cfc
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07192982B2
来源说明: uspto-grants-2007_03

反应 SMILES

C([O:3][C:4](=[O:20])[CH:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][OH:17])=[CH:9][CH:8]=1)C.O[C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[O:28][C:27]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[CH:26][C:25]2=[O:38].CC(OC(/N=N/C(OC(C)C)=O)=O)C.CCOC(/N=N/C(OCC)=O)=O>C1(C)C=CC=CC=1>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][CH2:16][O:17][C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[O:28][C:27]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)=[CH:26][C:25]3=[O:38])=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]