Magnesium → 3-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester

HRID 459170Notes

Reaction equation

HRID 459170 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C:4]([O:20][CH3:21])=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[Mg]>CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([O:20][CH3:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 5462224MagnesiumHCID 694217553-(3-Benzyloxy-phenyl)-2-methoxy-acrylic acid methyl ester

Product 1

HCID 588226203-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound from Step B was dissolved in methanol and treated with magnesium. The flask was placed in an ice bath for 5 min and then the reaction mixture was stirred at room temperature for 4 hours. Washed with HCl 3N and extracted with ether. Dry and concentrated to dryness to get the title compound.

Workup

  1. washWashed with HCl 3N
  2. extractionextracted with ether
  3. customDry
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-c4d368ff1fa04e8099d31c20eac2a16a
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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