3-(4-Benzyloxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester → 3-(4-Hydroxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester

HRID 459181Notes

Reaction equation

HRID 459181 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[C:9]([CH3:21])[CH:8]=1)[CH3:2]>C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([O:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:21])[CH:8]=1)[CH3:2]

Participants

3

Reactant 1

HCID 694253043-(4-Benzyloxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester

Product 1

HCID 588228333-(4-Hydroxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 3-(4-Benzyloxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester in ethyl acetate was treated with a catalytic amount of C—Pd (0.1 eq) and then H2 was bubbled through the mixture and stirred 2 hours. The mixture reaction was filtered through a pad of celite and concentrated in vacuo to give the title compound.

Workup

  1. customH2 was bubbled through the mixture
  2. customThe mixture reaction
  3. filtrationwas filtered through a pad of celite
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2adc4350357a44c5a8aba22a3e04847d
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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