Diisopropyl azodicarboxylate → HCID 69421933, compound

HRID 459280Notes

Reaction equation

HRID 459280 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][OH:17])=[CH:9][CH:8]=1)[CH3:2].[C:21]([Si:25]([CH3:41])([CH3:40])[O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH:38]=[CH:37][C:36](O)=[CH:35][CH:34]=2)=[CH:29][CH:28]=1)([CH3:24])([CH3:23])[CH3:22].CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:36]2[CH:35]=[CH:34][C:33]([C:30]3[CH:31]=[CH:32][C:27]([O:26][Si:25]([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:40])[CH3:41])=[CH:28][CH:29]=3)=[CH:38][CH:37]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

5

Reactant 3

HCID 5363146Diisopropyl azodicarboxylateHCID 18443695HCID 18443695, compoundHCID 58823028HCID 58823028, compound

Product 1

HCID 69421933HCID 69421933, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl)-2-methoxy-propionic acid ethyl ester and 4′-(tert-butyl-dimethyl-silanyloxy)-biphenyl-4-ol (Example 196, Step A) were treated under Mitsunobu procedure B (DIAD, toluene), to afford the title compound.

Sources & evidence

ORD record
ord-a18b349e154143eb9a3ff973fcf63967
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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