HRID459577

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID23704331

未命名化合物

结构：CCOC(=O)[C@H]1CC[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@H](NC(=O)OC(C)(C)C)C1

HCID58822150

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@H]1CC[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@H](NC(=O)c2nc3c(s2)CN(C)CC3)C1

HCID58822199

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

(1R*,2R*,4S*)-N2-tert-Butoxycarbonyl-N1-[(5-chloroindol-2-yl)carbonyl]-4-ethoxycarbonyl-1,2-cyclohexanediamine was treated with a saturated ethanol solution of hydrochloric acid and then condensed with lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine-2-carboxylate in a similar manner to Example 118 to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2982c4ceb9954bf1a1d1a3bb9263e046
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07192968B2
来源说明: uspto-grants-2007_03

反应 SMILES

C(O[C:6]([NH:8][C@@H:9]1[CH2:14][C@@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:12][CH2:11][C@H:10]1[NH:20][C:21]([C:23]1[NH:24][C:25]2[C:30]([CH:31]=1)=[CH:29][C:28]([Cl:32])=[CH:27][CH:26]=2)=[O:22])=[O:7])(C)(C)C.Cl.[CH3:34][N:35]1[CH2:40][CH2:39][C:38]2[N:41]=[C:42](C([O-])=O)[S:43][C:37]=2[CH2:36]1.[Li+]>C(O)C>[Cl:32][C:28]1[CH:29]=[C:30]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23]([C:21]([NH:20][C@@H:10]1[CH2:11][CH2:12][C@H:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:14][C@H:9]1[NH:8][C:6]([C:42]1[S:43][C:37]3[CH2:36][N:35]([CH3:34])[CH2:40][CH2:39][C:38]=3[N:41]=1)=[O:7])=[O:22])=[CH:31]2