反应详情

温度

44 °C

(−)-(4-Chloro-phenyl)-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester (90.0 g) was dissolved in diisopropylether (900 mL) at 55° C. The resulting mixture was polish filtered, the solution cooled to 44° C. over about 20 minutes and seeded. The resulting mixture was stirred for 1 hour at 44° C., cooled to 35° C. over 4 hours, then stirred at 35° C. for 2 hours to yield a thick suspension. The suspension was cooled to −5° C. over about 5 hours and then stirred at −5° C. The resulting crystals were filtered off with a centrifuge and washed with precooled (−5° C.) diisopropylether (100 mL). The wet product was dried at 30° C. to yield the title compound as a white crystalline solid, more specifically as white crystals, needles.

1. filtrationfiltered
2. temperaturecooled to 35° C. over 4 hours
3. stirringstirred at 35° C. for 2 hours
4. customto yield a thick suspension
5. temperatureThe suspension was cooled to −5° C. over about 5 hours
6. stirringstirred at −5° C
7. filtrationThe resulting crystals were filtered off with a centrifuge
8. washwashed with precooled (−5° C.) diisopropylether (100 mL)
9. customThe wet product was dried at 30° C.