Hydrochloric Acid → HCID 82243366, compound

HRID 459854Notes

Reaction equation

HRID 459854 reaction equation
O=[C:2]([CH3:8])[CH2:3][C:4]([O:6][CH3:7])=[O:5].C(OC(=O)C)(=O)C.[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N+:23]([O-])=CC=[CH:20]2.Cl>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[C:2]([CH2:3][C:4]([O:6][CH3:7])=[O:5])[CH:8]=[CH:20]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 7757Methyl acetoacetateHCID 7918Acetic AnhydrideHCID 123789256-Chloro-1-oxo-1lambda~5~-quinoline

Product 1

HCID 82243366HCID 82243366, compound

Conditions

Temperature
40 °C

Procedure

Methyl 3-oxobutyrate was added to an acetic anhydride solution of 6-chloroquinoline 1-oxide, followed by 30 minutes of stirring at an oil bath temperature of 40° C. Thus obtained compound was added to 10% hydrochloric acid and the mixture was reacted at room temperature to obtain methyl (6-chloroquinolin-2-yl)acetate. The compound was further treated in a similar manner to Reference Example 11, Example 22 and Example 4, successively, to obtain an objective compound.

Workup

  1. customthe mixture was reacted at room temperature

Sources & evidence

ORD record
ord-88f34cd4bdf5492599dd48c5a97e0a6b
Source dataset
uspto-grants-2007_03
Patent number
US07196080B2

Reaction notes

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