反应详情

Combine 4-(4-cyano-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester Example 9, step 1, 215 mg, 0.71 mmol) and potassium carbonate (49 mg, 0.36 mmol) in DMSO (35 mL) at 0° C. Then add dropwise hydrogen peroxide (213 μL). Then stir at room temperature for 1 h. Quench the reaction with water (10 mL) and extract with EtOAc/hexanes (2/1, 3×20 mL). Combine the organic layers, dry over magnesium sulfate, filter and concentrate to give the title compound.

1. customat 0° C
2. customQuench
3. customthe reaction with water (10 mL)
4. extractionextract with EtOAc/hexanes (2/1, 3×20 mL)
5. dry with materialCombine the organic layers, dry over magnesium sulfate
6. filtrationfilter
7. concentrationconcentrate