Trifluoroacetic acid → HCID 57989597, compound

HRID 45993Notes

Reaction equation

HRID 45993 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][C@H:14]2[CH2:22][O:23][CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])(=[O:12])=[O:11])=[C:5]([CH3:32])[CH:4]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][C@H:14]2[CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])(=[O:12])=[O:11])=[C:5]([CH3:32])[CH:4]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57989587HCID 57989587, compound

Product 1

HCID 57989597HCID 57989597, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cold (0° C.) solution of (S)-tert-butyl 2-((1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)indolin-2-yl)methoxy)acetate (0.5 mmol) in dichloromethane (6 ml) was added TFA (1.5 ml) and the reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the crude product was used in the next step.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-2632ec5561054550ad1e95e54da237c4
Source dataset
uspto-grants-2013_09
Patent number
US08541573B2

Reaction notes

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