Benzylamine → Methyl 4-(benzylamino)-2,3,5,6-tetrafluorobenzoate

Temperature

5 °C

Methyl pentafluorobenzoate (41.4 g, 183 mmol) was treated with N-methylpyrrolidinone (36.0 g) and the solution stirred and cooled to 5° C. under a N2 atmosphere. Benzylamine (19.8 g, 185 mmol) was added dropwise over 27 min. at 5° C.–20° C. The resulting thick yellow slurry was cooled to 2° C. over 25 min. and N,N-diisopropyl ethylamine (27.0 g, 209 mmol) was added over 30 min. at 3° C.–10° C. The mixture was allowed to warm to 18° C. and stirred for 2 hrs. It was then heated to 60° C. and stirred another 2 hs at 58° C.–67° C. The resulting solution was cooled to room temperature and stirred overnight. The mixture was treated with toluene (200 mL) and methyl tert-butyl ether (120 mL) and extracted with water (150 mL) followed by 10% aqueous acetic acid (2×50 mL). The organic layer was concentrated to a solid, which was recrystallized from toluene (45 mL) and heptane (50 mL). After cooling to −20° C., the crystals were collected, washed with heptane (2×25 mL) and vacuum dried at 35° C. to give methyl 4-(benzylamino)-2,3,5,6-tetrafluorobenzoate (49.3 g, 157 mmol): mp 96–97° C.

1. temperatureThe resulting thick yellow slurry was cooled to 2° C. over 25 min.
2. temperatureto warm to 18° C.
3. stirringstirred for 2 hrs
4. temperatureIt was then heated to 60° C.
5. stirringstirred another 2 hs at 58° C.–67° C
6. temperatureThe resulting solution was cooled to room temperature
7. stirringstirred overnight
8. extractionextracted with water (150 mL)
9. concentrationThe organic layer was concentrated to a solid, which
10. customwas recrystallized from toluene (45 mL) and heptane (50 mL)
11. temperatureAfter cooling to −20° C.
12. customthe crystals were collected
13. washwashed with heptane (2×25 mL) and vacuum
14. customdried at 35° C.

ORD record

ord-4c3574e9322e4f4db5720275e5d42765

Source dataset

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07196090B2