Methylamine → HCID 9983637, compound

HRID 459983Notes

Reaction equation

HRID 459983 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([N:12]2[C:17]3=[N:18][C:19](S(C)=O)=[N:20][CH:21]=[C:16]3[CH2:15][N:14]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])[C:13]2=[O:37])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[CH3:38][NH2:39].O1CCCC1>O1CCOCC1>[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([N:12]2[C:17]3=[N:18][C:19]([NH:39][CH3:38])=[N:20][CH:21]=[C:16]3[CH2:15][N:14]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])[C:13]2=[O:37])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 86590948HCID 86590948, compound

Product 1

HCID 9983637HCID 9983637, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a 100-mL round-bottomed flask was added Ethyl-4-[3-(2,6-difluoro-3,5-dimethoxy-phenyl)-7-methylsulfinyl-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-yl]-cyclohexanecarboxylate (820 mg, 1.52 mmol), dioxane(60 mL), then a 2 M solution of methylamine in tetrahydrofuran (7.6 mL, 15.2 mmol), and the solution was heated to 60° C. under an atmosphere of nitrogen for 5 hours. The solution was then concentrated in vacuo, and reacted further without purification: LRMS: 506.2 (M+H).

Workup

  1. concentrationThe solution was then concentrated in vacuo
  2. customreacted further without purification

Sources & evidence

ORD record
ord-058e43178f0d4c0ba2fac5f041a0001b
Source dataset
uspto-grants-2007_03
Patent number
US07196090B2

Reaction notes

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