Lithium Hydroxide → HCID 68562116, compound

HRID 459995Notes

Reaction equation

HRID 459995 reaction equation
[CH:1]([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][C:17]1[CH:21]=[C:20]([C:22]3[S:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[O:19][N:18]=1)[C:11]([C:28]([O:30]CC)=[O:29])=[CH:10]2)=[O:6])([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1.CO>[CH:1]([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:16][C:17]1[CH:21]=[C:20]([C:22]3[S:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[O:19][N:18]=1)[C:11]([C:28]([OH:30])=[O:29])=[CH:10]2)=[O:6])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68561813HCID 68561813, compound

Product 1

HCID 68562116HCID 68562116, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6.21 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2,5-dicarboxylic acid 2-ethyl ester 5-isopropyl ester in 100 ml THF and 40 ml MeOH 52 ml of an aqueous 1M LiOH solution were added and stirred for 2 h. The organic solvents were removed under reduced pressure and the residue acidified with 2 M hydrochloric acid to pH 2. The precipitated product was collected by filtration and dried over P2O5 in vacuo to yield a white solid. Yield: 5.77 g.

Workup

  1. customThe organic solvents were removed under reduced pressure
  2. filtrationThe precipitated product was collected by filtration
  3. dry with materialdried over P2O5 in vacuo
  4. customto yield a white solid

Sources & evidence

ORD record
ord-60c43b4d9329448198f687bbdb19cd23
Source dataset
uspto-grants-2007_03
Patent number
US07196103B2

Reaction notes

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