反应详情

A mixture of 4-hydroxy-3-methylbenzaldehyde (0.658 g), benzyl bromide (0.812 g) and potassium carbonate (1.0 g) in acetone (30 ml) was stirred and heated under reflux for 6 hours. The solvent was removed and the residues were partitioned between water and ethyl acetate. The aqueous phase was further extracted with ethyl acetate and the combined organic layers were washed with brine and dried. Removal of the solvent gave the title compound as a brown oil.

1. temperatureheated
2. temperatureunder reflux for 6 hours
3. customThe solvent was removed
4. customthe residues were partitioned between water and ethyl acetate
5. extractionThe aqueous phase was further extracted with ethyl acetate
6. washthe combined organic layers were washed with brine
7. customdried
8. customRemoval of the solvent