反应详情

To a degassed solution of 4-methoxybenzeneboronic acid (1.51 g, 10 mmol), 3-bromo-4-chlorobenzaldehyde (2 g, 9.13 mmol), and potassium carbonate (3.13 g, 22.8 mmol) in toluene/ethanol 2/1, (60 mL), Pd(PPh3)4 (130 mg, 1 mol %) is added and the mixture is degassed for further 5 minutes. The mixture is then refluxed for 2 days. The mixture was partitioned between ethyl acetate and water and extracted. The organic solvent was dried over sodium sulphate, removed under reduced pressure, and the residue purified by column chromatography (heptane/ethyl acetate 19/1 to afford 1.41 g of product.

1. customthe mixture is degassed for further 5 minutes
2. temperatureThe mixture is then refluxed for 2 days
3. customThe mixture was partitioned between ethyl acetate and water
4. extractionextracted
5. dry with materialThe organic solvent was dried over sodium sulphate
6. customremoved under reduced pressure
7. customthe residue purified by column chromatography (heptane/ethyl acetate 19/1