反应详情

温度

0 °C

A solution of 3-(indol-5-yl)-4-methoxybenzaldehyde (0.50 g, 2.0 mmol) in DMF (10 mL) was cooled to 0° C. and NaH (60% dispersion in mineral oil, 0.14 g, 3.0 mmol) was added. The mixture was stirred at 0° C. for 45 minutes, then methyl iodide (0.34 g, 4.4 mmol) was added and the reaction was stirred for 16 hours at room temperature. The mixture was then poured into water and extracted with ethyl acetate, washed with water and dried over sodium sulphate. The solvent was removed in vacuo and the crude was purified by column chromatography (hexane/ethyl acetate 7/3) to give 0.48 g of title compound.

1. stirringthe reaction was stirred for 16 hours at room temperature
2. extractionextracted with ethyl acetate
3. washwashed with water
4. dry with materialdried over sodium sulphate
5. customThe solvent was removed in vacuo
6. customthe crude was purified by column chromatography (hexane/ethyl acetate 7/3)