反应详情

温度

23 °C

2-Amino-3-picoline (1.00 mL, 8.62 mmol) was dissolved in DMF (30 mL) at 23° C., and treated with solid carboethoxy-phthalimide (1.89 g, 8.64 mmol), followed by TEA (1.44 mL, 10.3 mmol). The resulting solution was stirred at 23° C. for 15 h. After 15 h, the mixture was diluted with EtOAc (50 mL), and washed with saturated NaCl (1×50 mL), H2O (1×50 mL), dried (MgSO4), and concentrated in vacuo to a yellow solid. Purification over silica gel (0 to 50% EtOAc/Hexanes) provided the title compound as a white solid.

1. waitAfter 15 h
2. washwashed with saturated NaCl (1×50 mL), H2O (1×50 mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo to a yellow solid
5. customPurification over silica gel (0 to 50% EtOAc/Hexanes)