反应详情

To a stirred solution of 2-[3-(benzyloxycarbonylamino-methyl)-piperidin-1-yl]-thiazole-4-carboxylic acid ethyl ester (439 mg, 1.15 mmol) in THF (5 mL) at RT, a 1M solution of LiOH (aq) (1.72 mL, 1.72 mmol) was added. After 16 h the solvent was evaporated in vacuo. The residue was treated with brine (25 mL) and acidified to pH 1 with 2N HCl (aq) then extracted with EtOAc (30 mL). The organic layer was separated, dried over Na2SO4, filtered and the solvent evaporated in vacuo to yield the title compound as a colorless oil. MS m/z: 355.9 (M+H). Calc'd. for C16H25N3O4S-355.45.

1. customAfter 16 h the solvent was evaporated in vacuo
2. additionThe residue was treated with brine (25 mL)
3. extractionthen extracted with EtOAc (30 mL)
4. customThe organic layer was separated
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe solvent evaporated in vacuo