HCID 18445337, compound → HCID 18771654, compound

HRID 460222Notes

Reaction equation

HRID 460222 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[N:9]=2)[CH2:4][CH2:3]1>[OH-].[OH-].[Pd+2].CCO>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[N:9]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 18445337HCID 18445337, compound

Product 1

HCID 18771654HCID 18771654, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

A solution of 1′-methyl-1′,2′,3′,6′-tetrahydro-[2,4′]bipyridinyl-6-ylamine (1.1 g, 5.8 mmol) and EtOH (30 mL) was hydrogenated over 20% Pd(OH)2/C (0.3 g) at 40 psi and RT. After 16 h, the mixture was filtered through Celite® and concentrated in vacuo to give the desired compound as a yellow solid. MS m/z: 192.1 (M+H). Calc'd for C11H17N3-191.27.

Workup

  1. filtrationthe mixture was filtered through Celite®
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-577d6e3bb5f7448f91dc08506bfb4070
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

Loading…