Potassium Carbonate → (s)-4-(8-Glycidyloxy-2h-chromen-3-ylcarbonyl)morpholine

HRID 460549Notes

Reaction equation

HRID 460549 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][CH2:9][C:8]([C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])=[CH:7]2.C(=O)([O-])[O-].[K+].[K+].S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:30][C@H:31]1[O:33][CH2:32]1)(=O)=O>>[CH2:30]([O:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][CH2:9][C:8]([C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])=[CH:7]2)[C@H:31]1[O:33][CH2:32]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 105633504-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholineHCID 10868995(S)-(+)-Glycidyl-4-nitrobenzoate

Product 1

HCID 60077970(s)-4-(8-Glycidyloxy-2h-chromen-3-ylcarbonyl)morpholineYield 77.3%

Procedure

By the reactions in the same manner as in Starting Material Synthesis Example 1 using 4-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholine (3.3 g), potassium carbonate (3.5 g) and (S)-glycidyl nosylate (3.3 g), the title compound (3.1 g) was obtained as a brown oil.

Sources & evidence

ORD record
ord-f99ee1041e41463988e99af2ee3c7ef9
Source dataset
uspto-grants-2007_03
Patent number
US07196199B2

Reaction notes

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