Hydrochloric Acid → HCID 135794329, compound

HRID 460627Notes

Reaction equation

HRID 460627 reaction equation
COC[O:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]3[O:18][C:17]([S:19][CH3:20])=[N:16][N:15]=3)[O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1.Cl>C1COCC1>[OH:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]3[O:18][C:17]([S:19][CH3:20])=[N:16][N:15]=3)[O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22729151HCID 22729151, compound

Product 1

HCID 135794329HCID 135794329, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution (20 ml) of 5-(4-(methoxymethyloxy)benzo(b)furan-2-yl)-2-methylthio-1,3,4-oxadiazole (1.0 g) in THF was added 2N aqueous hydrochloric acid (3.0 ml), and the mixture was refluxed under heating for 7 hr. The solvent was evaporated under reduced pressure to give the title compound (0.62 g) as yellow crystals.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 7 hr
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-4ed2213695f948e38c890b8e9831ae96
Source dataset
uspto-grants-2007_03
Patent number
US07196199B2

Reaction notes

Loading…