Diethylamine → HCID 60077996, compound

HRID 460632Notes

Reaction equation

HRID 460632 reaction equation
[OH:1][C@@H:2]([CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:33]=[CH:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=2)[CH2:20][CH2:19]1)[CH2:3][O:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]([OH:16])=O)[O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1.[CH2:34]([NH:36][CH2:37][CH3:38])[CH3:35].P(C#N)(OCC)(OCC)=O>>[OH:1][C@@H:2]([CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([C:24]2[CH:33]=[CH:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=2)[CH2:22][CH2:23]1)[CH2:3][O:4][C:5]1[C:13]2[CH:12]=[C:11]([C:14]([N:36]([CH2:37][CH3:38])[CH2:34][CH3:35])=[O:16])[O:10][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 8021DiethylamineHCID 76257Diethyl cyanophosphonateHCID 60078011HCID 60078011, compound

Product 1

HCID 60077996HCID 60077996, compound

Procedure

By the reactions in the same manner as in as in Example 3 using (S)-4-(2-hydroxy-3-(4-(naphthalen-2-yl)piperidino)propyloxy)benzo(b)furan-2-carboxylic acid Starting Material Synthesis Example 22, diethylamine (0.24 ml) and diethyl cyanophosphate (0.5 ml), the title compound (0.61 g) was obtained as a brown oil.

Sources & evidence

ORD record
ord-6e6e358c292c4ee885d6864da272cf63
Source dataset
uspto-grants-2007_03
Patent number
US07196199B2

Reaction notes

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