反应详情

A suspension of platinum (200 mg) in 2-propanol (50 ml.) and 1 N sulfuric acid (20 ml.) was briefly hydrogenated (3.4 atm) and 5-(3-azidopropyl)-5-methyl-2,4-imidazolidinedione (3.94 g., 0.020 mol) was added. Hydrogenation was continued for 7 hours at 3.4 atmospheres. The catalyst was removed by filtration and the filtrate concentrated to a small volume, addition of 2-propanol afforded 5-(3-aminopropyl)-5-methyl-2,4-imidazolidine dione hemisulfate as prisms, 4.40 g. (0.019 mol, 96%); m.p. 183°-185° C. after one crystallization from aqueous 2-propanol.

1. additionwas added
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate concentrated to a small volume, addition of 2-propanol