Water → 4-(2,4-Dichloro-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

HRID 460827Notes

Reaction equation

HRID 460827 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:5][C:4]=1[C:14]1([OH:22])[CH2:18][S:17][C:16](=[N:19][CH3:20])[N:15]1[CH3:21].C(N(CC)CC)C.O>CO>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([S:10](=[O:13])(=[O:12])[NH2:11])=[CH:5][C:4]=1[C:14]1([OH:22])[CH2:18][S:17][C:16](=[N:19][CH3:20])[N:15]1[CH3:21]

Participants

5

Reactant 3

HCID 962WaterHCID 8471TriethylamineHCID 213947684-(2,4-Dichloro-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

Product 1

HCID 213947694-(2,4-Dichloro-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.4 g of 4-(2,4-dichloro-5-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide in 60 ml of methanol were combined with 4 ml of triethylamine, heated for 5 minutes to 50° C on the steam bath and precipitation was effected with 250 ml of water. M.p. 187°-190° C (decomposition).

Workup

  1. temperatureheated for 5 minutes to 50° C on the steam bath and precipitation

Sources & evidence

ORD record
ord-036c84906728406fba97afbd7312af42
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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