Potassium Carbonate → HCID 21395237, compound

HRID 461007Notes

Reaction equation

HRID 461007 reaction equation
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:17][CH2:18][CH2:19][C:20]([O:22][CH3:23])=[O:21].C(=O)([O-])[O-].[K+].[K+]>>[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 107604Methyl 4-bromobutyrateHCID 118120N-4-Piperidylbenzamide

Product 1

HCID 21395237HCID 21395237, compoundYield 82%

Procedure

An intimate mixture of 4-benzamidopiperidine (2.0g.), methyl 4-bromobutyrate (2.0g.) and potassium carbonate (1.5 g.) was stirred and heated on a steam bath for 15 minutes. An exothermic reaction occurred and the semi-molten mixture set solid. Trituration with water (20 ml.) and filtration provided the title compound (2.41 g., 82%), m.p. 116° (Found: C, 67.10; H, 8.00; N, 9.39; C17H24N2O3 requires C, 67.08; H, 7.95; N, 9.20%).

Workup

  1. temperatureheated on a steam bath for 15 minutes
  2. customAn exothermic reaction
  3. filtrationTrituration with water (20 ml.) and filtration

Sources & evidence

ORD record
ord-a1aa075fa9874516a25bea330ba37369
Source dataset
uspto-grants-1977_12
Patent number
US04061758

Reaction notes

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