反应详情

To 5.0 g (25 m mole) of 2-azatridecanone in 100 ml of benzene is added dropwise 3.9 g (25 m mole) of phosphorous oxychloride and the mixture stirred at room temperature for a period of 4 hours. α-Methyl-p-phenylbenzylamine hydrochloride, 5.3 g (23 m mole), is added and stirred at room temperature for 1 hour and refluxed for an additional 4 hours. Hydrochloric acid, 2N, is added and the benzene layer separated, dried over sodium sulfate, and evaporated to dryness. The crude product is crystallized from acetone, M.P. 135°-142° C.

1. stirringstirred at room temperature for 1 hour
2. temperaturerefluxed for an additional 4 hours
3. customthe benzene layer separated
4. dry with materialdried over sodium sulfate
5. customevaporated to dryness
6. customThe crude product is crystallized from acetone, M.P. 135°-142° C.