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HRID461105

反应详情

EQUATION

反应方程式

HRID 461105 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：Br.CN=C1SCC(O)(c2ccc(Cl)c(S(N)(=O)=O)c2)N1C
HCID22760640

未命名化合物

PRODUCTS

生成物

1
结构：CN=C1SCC(O)(c2ccc(Cl)c(S(N)(=O)=O)c2)N1C
HCID72156

2-Chloro-5-(4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl)benzenesulfonamide

C11H14ClN3O3S2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

10 g of powdered 4-(4-chloro-3-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide were dissolved in 500 ml of water at 50° C, while stirring, 100 ml of saturated sodium bicarbonate solution were added and the solution was thoroughly stirred for 2 hours at 5°-10° C, 4-(4-chloro-3-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol was filtered off and washed several times with water. Melting point: 187°-188° C (decomposition).

WORKUP

后处理

  1. stirringthe solution was thoroughly stirred for 2 hours at 5°-10° C
  2. filtration4-(4-chloro-3-sulfamoylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol was filtered off
  3. washwashed several times with water