Basic information
- CAS
56488-58-5- Standard SMILES
CN=C1SCC(O)(c2ccc(Cl)c(S(N)(=O)=O)c2)N1C- InChIKey
VYBZOPZNLLIEFX-UHFFFAOYSA-N- Molecular formula
- C11H14ClN3O3S2
- Average molar mass
- 335.8 g/mol
- Monoisotopic mass
- 335.0165114
Overview
Tizolemide is an alkaline sulfonamide-based diuretic. Tizolemide inhibits sodium reabsorption in the distal convoluted tubules.
Names & identifiers
- Preferred name
- Tizolemide
- IUPAC
- 2-chloro-5-(4-hydroxy-3-methyl-2-methylimino-1,3-thiazolidin-4-yl)benzenesulfonamide
- English name
- Tizolemide
- Molecular formula
- C11H14ClN3O3S2
- Molecular weight
- 335.83
Names & synonyms
Tizolemide56488-58-5TizolemidaTizolemidumP60K8QK3AADTXSID008665672-Chloro-5-(4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl)benzenesulfonamidetizolemidRefChem:190189DTXCID008148412-chloro-5-(4-hydroxy-3-methyl-2-methylimino-1,3-thiazolidin-4-yl)benzenesulfonamide2-Chloro-5-(4-hydroxy-3-methyl-2-(methylimino)thiazolidin-4-yl)benzenesulfonamide
Show more names
2-Chloro-5-[4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl]benzenesulfonamideBenzenesulfonamide, 2-chloro-5-[4-hydroxy-3-methyl-2-(methylimino)-4-thiazolidinyl]-
Tizolemidum [INN-Latin]Tizolemide [INN:BAN]Tizolemida [INN-Spanish]UNII-P60K8QK3AAHOE 740TIZOLEMIDE [INN]Hoe-740orb2802377
Database identifiers
- CAS
56488-58-5- PubChem CID
- 72156
- DTXSID
Properties
Computed structural properties
- XLogP
- 0.6
- Topological polar surface area
- 130 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 2
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 508
Physicochemical properties
- Boiling point
- 568.9 · 568.9±60.0 °C(Predicted)
- Density
- 1.59 · 1.59±0.1 g/cm3(Predicted)
- pka
- 9.43 · 9.43±0.20(Predicted)
- FDA UNII
- 60 K8QK3AA · P60K8QK3AA
Chemistry & industry
Applications
UsesTizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin[1][2].
Suppliers1 total
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
Related reactions
11 records
Compound notes
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