Hydrochloric Acid → 4-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrochloride

HRID 461116Notes

Reaction equation

HRID 461116 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:18])[CH2:12][S:11][C:10](=[N:13][CH:14]([CH3:16])[CH3:15])[N:9]2[CH3:17])=[CH:4][C:3]=1[S:19](=[O:22])(=[O:21])[NH2:20].Cl>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:18])[CH2:12][S:11][C:10](=[N:13][CH:14]([CH3:16])[CH3:15])[N:9]2[CH3:17])=[CH:4][C:3]=1[S:19](=[O:21])(=[O:22])[NH2:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 227604674-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol

Product 1

HCID 227606504-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 6 g of 4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4ol in 30 ml of ethyl acetate was made acid by adding, dropwise, 15% ethanolic hydrochloric acid. The solution was triturated to crystallize, allowed to stand over night at 0° C and the crystals were filtered off.

Workup

  1. additionby adding
  2. customThe solution was triturated
  3. customto crystallize
  4. waitto stand over night at 0° C
  5. filtrationthe crystals were filtered off

Sources & evidence

ORD record
ord-b086f8b8aa204d068acb66876ac3fcae
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

Loading…