Triethylamine → 4'-Chloro-3'-o-chlorobenzylsulfamoylacetophenone

HRID 461184Notes

Reaction equation

HRID 461184 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[S:11](Cl)(=[O:13])=[O:12].[Cl:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18][NH2:19].C(N(CC)CC)C>C(O)(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[S:11](=[O:13])(=[O:12])[NH:19][CH2:18][C:17]1[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=1[Cl:15]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 666482-ChlorobenzylamineHCID 126197955-Acetyl-2-chlorobenzene-1-sulfonyl chloride

Product 1

HCID 227604124'-Chloro-3'-o-chlorobenzylsulfamoylacetophenone

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

25.5 g of 4'-chloro-3'-chlorosulfonylacetophenone were reacted with 16 g of o-chloro-benzyl amine and 25.5 g of triethyl amine and worked up. Colorless crystals from isopropanol (active charcoal), melting point: 102° C.

Sources & evidence

ORD record
ord-108b97b5b27c4445a5f7eaf76a37c1da
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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