Potassium Carbonate → HCID 21393400, compound

HRID 461320Notes

Reaction equation

HRID 461320 reaction equation
C(=O)([O-])[O-].[K+].[K+].[Cl-].[NH2:8][C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Br:23]>C(O)CC>[NH:8]=[C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N:10]1[CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Br:23]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21393395HCID 21393395, compound

Product 1

HCID 21393400HCID 21393400, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

To a suspension of 13.8 g of anhydrous potassium carbonate in 150 ml of anhydrous n-propanol is added 33.1 g of 2-amino-1-[[(o-bromophenyl)thio]methyl]pyrimidinium chloride, portionwise, under nitrogen, at room temperature, with stirring. Subsequently, the mixture is stirred and heated under reflux for 2 hours, filtered hot, and the filtrate concentrated in vacuo. The residue is partitioned between 200 ml each of water and ether, the ether layer is separated, dried, and concentrated to give about 28.7 g of the named compound, after recrystallization from pentane.

Workup

  1. stirringSubsequently, the mixture is stirred
  2. temperatureheated
  3. temperatureunder reflux for 2 hours
  4. filtrationfiltered hot
  5. concentrationthe filtrate concentrated in vacuo
  6. customThe residue is partitioned between 200 ml each of water and ether
  7. customthe ether layer is separated
  8. customdried
  9. concentrationconcentrated

Sources & evidence

ORD record
ord-b11bc97fc37946ceabdc0138d9f14314
Source dataset
uspto-grants-1977_12
Patent number
US04062846

Reaction notes

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