反应详情

To a solution of 42 g of the compound 10-keto-10,11-dihydrodibenzo(b,f)-oxepine in 200 ml of dry ethanol a solution of sodiumethoxide (7 g of sodium in 500 ml of ethanol) is added dropwise. After stirring the mixture for 30 minutes 16.2 ml of methylvinylketon in 50 ml of ethanol are added, whereupon the solution is refluxed for 1 hour. The solution is cooled then and poured into 2 N HCl. After extracting into ether, washing the ether layer with water (till neutral) and drying the etherial phase, the solvent is evaporated.

1. additionare added, whereupon the solution
2. temperatureis refluxed for 1 hour
3. temperatureThe solution is cooled
4. extractionAfter extracting into ether
5. washwashing the ether layer with water (till neutral)
6. customdrying the etherial phase
7. customthe solvent is evaporated