Guanidine Hydrochloride → HCID 58930269, compound

HRID 46139Notes

Reaction equation

HRID 46139 reaction equation
[OH:1][C:2]([CH3:11])([CH:8]([CH3:10])[CH3:9])[C:3](OCC)=[O:4].Cl.[NH2:13][C:14](N)=[NH:15].C([O-])([O-])=O.[K+].[K+]>C(O)C>[NH2:15][C:14]1[O:1][C:2]([CH:8]([CH3:10])[CH3:9])([CH3:11])[C:3](=[O:4])[N:13]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 11430Potassium CarbonateHCID 58929656HCID 58929656, compound

Product 1

HCID 58930269HCID 58930269, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl 2-hydroxy-2,3-dimethylbutanoate (2.92 g, 18.2 mmol), guanidine hydrochloride (1.74 g, 18.2 mmol), and K2CO3 (2.52 g, 18.2 mmol) in 99.5% ethanol (40 mL) was stirred under reflux for 20 h. The solvent was removed, and the residue was purified by silica gel flash chromatography (ethyl acetate/methanol 9:1) to give the product as a white solid.

Workup

  1. temperatureunder reflux for 20 h
  2. customThe solvent was removed
  3. customthe residue was purified by silica gel flash chromatography (ethyl acetate/methanol 9:1)

Sources & evidence

ORD record
ord-aa2b4b99706d4e52bae183b3613215c1
Source dataset
uspto-grants-2013_09
Patent number
US08541592B2

Reaction notes

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