反应详情

A stirred mixture of 1.83 g. (0.01 mole) of 2-phenylethenesulfonamide, 3.45 g. (0.025 mole) of potassium carbonate and 4.0 g. (0.015 mole) of 4-(3-phenylpropyl)piperidinocarbonyl chloride, in 75 ml. of chloroform is heated under reflux for 22 hours. The solvent is then removed by evaporation in vacuo, and to the residue is added 75 ml of 0.5N sodium hydroxide and 35 ml. of ether. The mixture is stirred for 1 hour, and then the solid which remains undissolved is removed by filtration. This affords 1.84 g. (ca. 41% yield) of the title compound as a mixture of its sodium and potassium salts.

1. additionA stirred mixture of 1.83 g
2. temperatureunder reflux for 22 hours
3. customThe solvent is then removed by evaporation in vacuo
4. additionto the residue is added 75 ml of 0.5N sodium hydroxide and 35 ml
5. customthe solid which remains undissolved is removed by filtration