反应详情

To a solution of 21.8 g (0.20 mole) of 2-cyanothiophene in 500 ml of ethanol, 13.9 g (0.20 mole) of hydroxylamine HCl is added, followed by the addition of 13.8 g (0.10 mole) of K2CO3 in 50 ml of water. The mixture is refluxed for 16 hours, cooled and diluted with 200 ml of water. After removing the ethanol in vacuo, the product precipitates out of the aqueous residue. It is collected by filtration, washed with water and dried to yield 22.4 g (80%) of product, m.p. 70°-75°.

1. temperatureThe mixture is refluxed for 16 hours
2. temperaturecooled
3. customAfter removing the ethanol in vacuo
4. customthe product precipitates out of the aqueous residue
5. filtrationIt is collected by filtration
6. washwashed with water
7. customdried