Thiophosgene → HCID 21390707, compound

HRID 462181Notes

Reaction equation

HRID 462181 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[N:9]=2)=[CH:4][CH:3]=1.[C:19](Cl)(Cl)=[S:20]>O1CCCC1>[N:1]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[N:9]=2)=[CH:4][CH:3]=1)=[C:19]=[S:20]

Participants

4

Reactant 2

HCID 10040ThiophosgeneHCID 21942426HCID 21942426, compound

Product 1

HCID 21390707HCID 21390707, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 5-(4-aminophenyl)-3-(3-pyridyl)-1,2,4-oxadiazole in tetrahydrofuran is reacted with thiophosgene according to Example 14 to give the title compound in 30% yield, m.p. 121°-123°.

Sources & evidence

ORD record
ord-90150c5e7e9a46eabce81c66f75ddd76
Source dataset
uspto-grants-1977_12
Patent number
US04065563

Reaction notes

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